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Genome 4.2 SP8 supports VS2013 and .NET 4.5 - Thursday, October 24, 2013
Genome v4.2.9 provides integration to Microsoft Visual Studio 2013 with the same functionality as for VS2010 and VS2012. Also with this update the DataDomain schema projects can be compiled to .NET 4.5 and .NET 4.5.1 too. The service pack contains a few minor fixes in the runtime too.  
Genome 4.2 SP7 released - Wednesday, May 01, 2013
With a few fixes and a small feature!  
Genome 4.2 SP6 supports VS2012 RTM - Friday, August 24, 2012
Genome v4.2.7 provides integration to Microsoft Visual Studio 2012 RTM with the same functionality as for VS2010. This release contains only this tool enhancement and no change in the runtime.  
Genome 4.2 SP5 with VS2012 RC support - Friday, June 29, 2012
Genome v4.2.6 provides integration to Microsoft Visual Studio 2012 RC with the same functionality as for VS2010. This release contains only this tool enhancement and no change in the runtime.

Important note: Visual Studio 2012 RC comes with a change in the MsBuild system, that causes the Genome builds fail (in VS2012 and also in VS2010) with the following error:
error MSB4185: The function "CurrentUICulture" on type "System.Globalization.CultureInfo" has not been enabled for execution.

This problem will be fixed my Microsoft in VS2012 RTM. In the meanwhile you have to set the environment variable “MSBUILDENABLEALLPROPERTYFUNCTIONS” to “1”. (You might need to restart Visual Studio).

Genome 4.2 SP2 (v4.2.3) released - Oct 29, 2010
With many fixes and small features!  
Genome 4.2 released - Feb 10, 2010
Supports now Visual Studio 2010!  
Updated roadmap - Dec 22, 2009
learn more about the upcoming Genome v4.2 release  
Genome 4.1 released - Mar 31, 2009
Read more about what's new in this release.  
New Product Video released - Jan 16, 2009
Get a quick overview of Genome v4.  
  FAQ: Why Genome?  
There are so many O/RM tools out there... What's Genome got to offer?

Before embarking on any hardcore marketing here, we'd like to stress that we recommend carrying out a simple sample implementation with the best couple of O/RM products that you have shortlisted. This should give you a sense of how mature they are and whether they meet your initial expectations as regards O/R mapping. It is also a very good way of investigating quality of support and documentation.

Now for the hardcore marketing...

Cutting edge technology for .NET
Genome was built for enterprise development and we have our track record, references and enterprise features to back up that claim.

Born and bred purely for the .NET Framework, Genome always keeps pace with the latest .NET technologies. A glance at our release history will show that Genome has kept at the forefront of developments in O/RM.

Not only do we make a point of hopping to the latest platform as soon as it is available, but we also make sure that Genome's set of features offers unique tools and capabilities to make your life as a developer easier. Genome's support of query encapsulation and reuse is a case in point and you can read more about this and other features in the Technical Reviewer's Guide. Or, if you would like more detail, browse Genome's online documentation.

Professional services
How quickly can you count on getting custom extensions or fixes from other vendors? This is often a problem with very large corporations (ever requested a feature or hotfix from a giant like Microsoft?) as well as with open source (would you really want to branch and merge with each release just to implement custom features yourself?).

Genome is backed up by a dedicated, professional team working full time to evolve Genome further. This means that new developments, extensions and bug fixes are available promptly, not just when somebody in the community happens to find the time. The same goes for our support services (please read more about Genome support, the public support newsgroup and various other services that are available). Whether you need e-mail support, a code review, architectural advice or even custom features, the Genome team will deliver it within an acceptable timeframe.

In this context, you may also wish to read the sections on LINQ2SQL and open source alternatives.